Proteomic analysis of colon and rectal carcinoma using standard and customized databases
نویسندگان
چکیده
Understanding proteomic differences underlying the different phenotypic classes of colon and rectal carcinoma is important and may eventually lead to a better assessment of clinical behavior of these cancers. We here present a comprehensive description of the proteomic data obtained from 90 colon and rectal carcinomas previously subjected to genomic analysis by The Cancer Genome Atlas (TCGA). Here, the primary instrument files and derived secondary data files are compiled and presented in forms that will allow further analyses of the biology of colon and rectal carcinoma. We also discuss new challenges in processing these large proteomic datasets for relevant proteins and protein variants.
منابع مشابه
Corrigendum: Proteomic analysis of colon and rectal carcinoma using standard and customized databases
The original version of this Data Descriptor contained a typographical error in the spelling of the author Xiaojing Wang which was incorrectly given as Xaojing Wang. This has now been corrected in the PDF and HTML versions of the Data Descriptor.
متن کاملProteomic Analysis of Gene Expression in Basal Cell Carcinoma
Background: Basal Cell Carcinoma (BCC) is a type of non-melanoma skin cancer. Alteration in gene expression is the important event that happens in cancer cell. Detection of this event is possible by proteomics techniques. Methods: Normal and tumor tissues were taken from BCC patient. Total proteins were purified by standard methods, and proteins were separated by two-dimensional electrophoresis...
متن کاملعوامل مؤثر بر بقاء بیماران مبتلا به سرطان کولورکتال با استفاده از توابع مفصل
Background & objectives: Competing risk data is one of the multivarite survival data. Competing risk data can be modelled using copula function. In this study we propose a bayesian modelling approach of competing risk data using the copula function.Methods: We used the data from colorectal cancer registyrarty in Tehran. After constructing likelihood function using Clayton copula by choosing app...
متن کاملOptimal timing of computed tomography for assessing lymph nodes after neoadjuvant chemoradiotherapy for rectal cancer
Background: This study assessed the optimal timing of computed tomography for detection of metastatic disease in locoregional lymph nodes in patients with rectal cancer who have undergone chemoradiotherapy. Materials and Methods: This observational retrospective study was performed in a single institution. All patients with locally advanced rectal cancer treated with chemoradiotherapy, followed...
متن کاملRisk of colorectal cancer in relation to frequency and total amount of red meat consumption. Systematic review and meta-analysis
INTRODUCTION The colon and rectum are common sites of food-related cancer in developed countries. Recent studies strongly suggest that red meat intake is associated with colon cancer, whereas for rectal cancer such an association still needs to be proved. The aim of the study was to assess the role of total amount and frequency of red meat intake in colorectal carcinogenesis based on published ...
متن کامل